Job Description

Senior Discovery Scientist (Contract)

Toronto, ON

Introduction

The Senior Scientist, Discovery will facilitate the characterization and advancement of new ligands being developed for the company's discovery oncology pipeline. This position will require development, optimization, and standardization of methods to characterize new ligands being investigated as potential radiopharmaceuticals. The ideal candidate will have technical experience with in vitro and cell-based assays, mammalian cell culture, confocal/fluorescent microscopy, and radiobinding assays. The Senior Scientist will work cross-functionally with members of the discovery and preclinical team to execute research activities on site and with external partners. This is a contract position that will require the successful candidate to be fully on-site at a lab in Toronto, Ontario.

Responsibilities

• Develop and perform biochemical and/or cell-based assays to characterize the activity of early-stage ligands, such as ELISAs, cytotoxicity assays, or fluorogenic reporter assays.
• Passage and prepare mammalian cells to be used in assays.
• Develop methods to assess compound affinity, retention, and internalization of compounds.
• Support the generation of in vitro assay data for established projects.
• Interface with external vendors to support early discovery activities.
• Critically assess data and methods, adapting and adjusting procedures as necessary.
• In conjunction with managers, establish priorities and meet timelines for key experiments.
• Provide clear communication of scientific data to co-workers through internal presentations and written methods.
• Support preclinical and late-stage assets as necessary.

Requirements

• M.Sc or Ph.D. in chemistry, biochemistry, chemical biology, pharmacy, or related discipline with 3+ years relevant postgraduate experience (industry preferred)
• Demonstrated success independently designing experiments and planning scientific projects.
• Experience with mammalian cell culture and aseptic techniques.
• Strong background in the development and optimization of cell-based reporter assays and cytotoxicity assays.
• Experience performing in vitro biochemical/biophysical assays.
• Familiarity with confocal microscopy, immunofluorescence and imaging of live/fixed cells.
• Ability to communicate scientific data effectively to an interdisciplinary team.
• Excellent problem-solving and decision-making skills.
• Working knowledge of MS Office, Graphpad Prism, and ChemDraw.
• Experience with radiobinding assays or handling of radioactive materials is an asset.
• Experience with protein purification and analysis methods is an asset.
• Travel for team and client meetings required.

What We Offer

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About Us

Brunel has a reputation for working with some of the best in the business. That’s what we continually strive for. Over 45 years, we’ve created a global network of interesting clients and talented individuals working together through a vast array of services.

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